My current main Manifesto is “START WARS!!! Grow art!” (Disclaimer: No we should not start actual wars). It takes the form of a propaganda-looking poster that was using during regimes to grab the attention of and communicate ideas to the masses.
The idea behind it is that design is by humans, for humans. Throughout history, artists and designers have used their works as a form of universal language to challenge an ongoing mindset. This is evident in movements such as Dada, where even Dada went against himself, Streamlining after the Machine Age, and even today we are trying to marry the idea of using technology into human-centric designs. Usually after periods of dispute, strong assertions were made using art to communicate to the masses and propose to them potential directions they could drive society towards as fellow members of society. They may not have been the most aesthetically pleasing (even that is subjective), but what mattered was the philosophy behind the works and the process of creating them. The most successful movements often differentiated themselves with stark contrasts with movements before, or coexisting with them.
So my vision statement and call to action would be for designers to aim to have a larger outreach and get more people to participate in expressing their personal opinions and owning their rights to having an opinion and making them feel that it that matters in society. As such, they have to be well-informed about the world around them and investigate disputes and their underlying reasons and encourage discussion about the current state of society and not just accept society as it is.